Fibrodysplasia Ossificans Progressiva and Pregnancy: A Case Series and Review of the Literature

Alexandra D Forrest; Danielle M Vuncannon; Jane E Ellis; Zvi Grunwald; Frederick S Kaplan

doi:10.1155/2022/9857766

Fibrodysplasia Ossificans Progressiva and Pregnancy: A Case Series and Review of the Literature

Case Rep Obstet Gynecol. 2022 Sep 16:2022:9857766. doi: 10.1155/2022/9857766. eCollection 2022.

Authors

Alexandra D Forrest¹, Danielle M Vuncannon¹, Jane E Ellis¹, Zvi Grunwald², Frederick S Kaplan³

Affiliations

¹ Department of Gynecology and Obstetrics, Emory University School of Medicine, 80 Jesse Hill Jr. Drive SE, Atlanta, GA 30303, USA.
² Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University Hospital, Suite 515, 1020 Walnut Street, Philadelphia, PA 19107, USA.
³ Department of Orthopedic Surgery and Medicine, The Perelman School of Medicine, University of Pennsylvania, Penn Musculoskeletal Center, Suite 600, 3737 Market Street, Philadelphia, PA 19104, USA.

Abstract

Objective: To evaluate maternal and fetal outcomes in pregnant patients with fibrodysplasia ossificans progressiva (FOP; OMIM#135100), an ultrarare genetic disorder characterized by progressive heterotopic ossification of soft tissues and cumulative disability.

Methods: This is a retrospective case series of three patients with FOP who were admitted to Grady Memorial Hospital in Atlanta, Georgia, from to February 2011 to July 2021.

Results: Three women delivered preterm infants at our institution. These cases posed unique anesthetic and obstetric technical challenges, particularly when securing the airway and performing cesarean delivery. Importantly, each patient received perioperative glucocorticoids for prevention of further heterotopic ossification.

Conclusion: FOP is a unique clinical diagnosis encountered by obstetricians and requires multidisciplinary management for optimal outcomes.

Publication types

Case Reports