Risk Factors for Colistin-Resistant Carbapenem-Resistant Klebsiella pneumoniae in the Postacute Care Setting

Helen L Zhang; Jennifer H Han; Zena Lapp; Evan Snitkin; Ellie J C Goldstein; Sean Muldoon; Pam Tolomeo; Ebbing Lautenbach

doi:10.1093/ofid/ofac452

Risk Factors for Colistin-Resistant Carbapenem-Resistant Klebsiella pneumoniae in the Postacute Care Setting

Open Forum Infect Dis. 2022 Sep 2;9(9):ofac452. doi: 10.1093/ofid/ofac452. eCollection 2022 Sep.

Authors

Helen L Zhang^{1

2}, Jennifer H Han^{1

2

3}, Zena Lapp⁴, Evan Snitkin⁵, Ellie J C Goldstein^{6

7}, Sean Muldoon⁸, Pam Tolomeo^{2

3}, Ebbing Lautenbach^{1

2

3}

Affiliations

¹ Division of Infectious Diseases, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
² Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
³ Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
⁴ Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, USA.
⁵ Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
⁶ R.M. Alden Research Laboratory, Santa Monica, California, USA.
⁷ Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, California, USA.
⁸ ScionHealth, Louisville, Kentucky, USA.

Abstract

We assessed risk factors for colistin resistance among carbapenem-resistant Klebsiella pneumoniae (CRKP) from 375 patients in long-term acute care hospitals. Recent colistin or polymyxin B exposure was associated with increased odds of colistin resistance (adjusted odds ratio = 1.11 per day of exposure, 95% confidence interval = 1.03-1.19, P = .007).

Keywords: carbapenem-resistant Klebsiella pneumoniae; colistin; long-term acute care hospitals.

Abstract

Grants and funding