Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics

Int J Toxicol. 2022 Dec;41(3_suppl):77-128. doi: 10.1177/10915818221124809. Epub 2022 Sep 30.

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Panthenol, Pantothenic Acid, and 5 derivatives as used in cosmetics. These ingredients named in this report are reported to function in cosmetics as hair conditioning agents, and Panthenol also is reported to function as a skin-conditioning agent-humectant and a solvent. The Panel reviewed relevant data for these ingredients, and concluded that these 7 ingredients are safe in cosmetics in the present practices of use concentration described in this safety assessment.

Keywords: cosmetics; panthenol; pantothenic acid; safety.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Consumer Product Safety*
  • Cosmetics* / toxicity
  • Hygroscopic Agents
  • Pantothenic Acid / analogs & derivatives
  • Pantothenic Acid / toxicity
  • Risk Assessment
  • Solvents

Substances

  • Cosmetics
  • Hygroscopic Agents
  • Solvents
  • Pantothenic Acid
  • dexpanthenol