Embedding Mn2+ in polymer coating on rod-like cellulose nanocrystal to integrate MRI and photothermal function

Yang Shen; Xin Li; Haitao Huang; Yu Lan; Lin Gan; Jin Huang

doi:10.1016/j.carbpol.2022.120061

Embedding Mn²⁺ in polymer coating on rod-like cellulose nanocrystal to integrate MRI and photothermal function

Carbohydr Polym. 2022 Dec 1:297:120061. doi: 10.1016/j.carbpol.2022.120061. Epub 2022 Sep 2.

Authors

Yang Shen¹, Xin Li², Haitao Huang³, Yu Lan¹, Lin Gan⁴, Jin Huang⁵

Affiliations

¹ State Key Laboratory of Silkworm Genome Biology, and Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
² Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
³ Department of Radiology, University of Minnesota, 420 Delaware St SE, Minneapolis, MN 55455, United States. Electronic address: [email protected].
⁴ State Key Laboratory of Silkworm Genome Biology, and Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China; School of Chemistry and Chemical Engineering, Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bintuan, Shihezi University, Shihezi 832003, China. Electronic address: [email protected].
⁵ State Key Laboratory of Silkworm Genome Biology, and Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China; School of Chemistry and Chemical Engineering, Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bintuan, Shihezi University, Shihezi 832003, China. Electronic address: [email protected].

PMID: 36184155
DOI: 10.1016/j.carbpol.2022.120061

Abstract

Grafting Mn ions on 1D particles can produce high-performance MRI agents. However, the motion of Mn ions may cause Mn aggregation and then attenuate imaging contrast. Here, we proposed an MRI-promotion strategy based on embedding Mn²⁺ into crosslinked polydopamine (PDA) coating on rod-like cellulose nanocrystals. The results indicate that the slow relaxation of PDA molecular chains restricts the motion of embedded Mn²⁺. When the embedded Mn²⁺ content raises up to 2.25 wt%, the particles display a longitudinal relaxivity of 38.08 mM^-1·s^-1. Such a relaxivity is over 6.6 times of the sample with adsorbed 0.65 wt% Mn²⁺. The aspect ratio of nanoparticles even increases from 14.2 to 20.7 as embedding Mn²⁺ concentration increases. Then, the photothermal conversion efficiency of nanoparticles increases from 17.7 % to 44.4 %. This high photothermal conversion efficiency contributes this kind of MRI agent with embedded Mn²⁺ to the application potential of integrating tumor diagnosis and treatment.

Keywords: Bio-based nano-contrast; Cellulose nanocrystal; Magnetic resonance imaging; Photothermal function; Rod-like nanoparticle.

MeSH terms

Cellulose*
Ions
Magnetic Resonance Imaging / methods
Nanoparticles* / chemistry
Polymers / chemistry

Substances

Ions
Polymers
Cellulose