Refractory pediatric acute myeloid leukemia expressing NUP98-NSD1 fusion gene responsive to chemotherapy combined with venetoclax and decitabine

Pediatr Blood Cancer. 2023 Mar;70(3):e30021. doi: 10.1002/pbc.30021. Epub 2022 Oct 2.

Authors

Huan Xu¹, Hui Yu¹, Jiawei Xu¹, Fen Zhou¹, Shuo Tang¹, Xingxing Feng¹, Quan Luo¹, Bingyu Zhang¹, Xiaoyan Wu¹, Runming Jin¹, Hongbo Chen¹

Affiliation

¹ Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

PMID: 36184746
DOI: 10.1002/pbc.30021

No abstract available

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Child
Decitabine / therapeutic use
Histone-Lysine N-Methyltransferase / genetics
Humans
Leukemia, Myeloid, Acute* / drug therapy
Leukemia, Myeloid, Acute* / genetics
Nuclear Pore Complex Proteins / genetics
Oncogene Proteins, Fusion / genetics
Oncogene Proteins, Fusion / metabolism

Substances

Decitabine
Histone-Lysine N-Methyltransferase
NSD1 protein, human
nuclear pore complex protein 98
Nuclear Pore Complex Proteins
Nup98 protein, human
NUP98-NSD1 protein, human
Oncogene Proteins, Fusion
venetoclax