Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Delta Variant Shedding in a Patient With AIDS: Case Report and Review of the Literature

Jillian L Peters; Amary Fall; Steven D Langerman; Margueritta El Asmar; Mari Nakazawa; Aishat Mustapha; Aaron A R Tobian; Heba H Mostafa; Joel N Blankson

doi:10.1093/ofid/ofac479

Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Delta Variant Shedding in a Patient With AIDS: Case Report and Review of the Literature

Open Forum Infect Dis. 2022 Sep 17;9(9):ofac479. doi: 10.1093/ofid/ofac479. eCollection 2022 Sep.

Authors

Jillian L Peters¹, Amary Fall², Steven D Langerman¹, Margueritta El Asmar¹, Mari Nakazawa¹, Aishat Mustapha¹, Aaron A R Tobian², Heba H Mostafa², Joel N Blankson¹

Affiliations

¹ Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
² Department of Pathology, Johns Hopkins Medicine, Baltimore, Maryland, USA.

Abstract

We describe the case of a patient with AIDS who had persistent infection with a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant for >80 days. The variant contained mutations that were not present in other Delta viruses in our hospital. Prolonged infection in immunosuppressed individuals may lead to evolution of SARS-CoV-2 lineages.

Keywords: COVID-19; SARS-CoV2; HIV; PLWH.