Gold(I)-Catalyzed Tandem Cyclization/Hydroarylation of o-Alkynylphenols with Haloalkynes

J Org Chem. 2022 Nov 4;87(21):14374-14383. doi: 10.1021/acs.joc.2c01804. Epub 2022 Oct 4.

Abstract

A convenient and mild protocol for the gold-catalyzed intermolecular coupling of o-alkynylphenols with haloalkynes to give vinyl benzofurans is reported. In this work, the gold catalyst SIPrAuCl and the co-catalyst NaBARF would corporately promote the intramolecular cyclization of the o-alkynylphenol to benzofuran, and then a selective hydroarylation of benzofuran to haloalkyne was catalyzed by the same catalysts. Computational studies suggest that the hydroarylation process takes place via a concerted nucleophilic attack pathway of the benzofuran to the C2 carbon of the activated haloalkyne, and reveal the original driving force of this hydroarylation process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbon*
  • Catalysis
  • Cyclization
  • Gold*
  • Molecular Structure

Substances

  • Gold
  • Carbon