Hold your horses: The receptor-binding domains of SARS-CoV-2, SARS-CoV, and hCoV-NL63 bind equine ACE2

Philipp Nawrath; Antoni G Wrobel

doi:10.1016/j.str.2022.09.003

Hold your horses: The receptor-binding domains of SARS-CoV-2, SARS-CoV, and hCoV-NL63 bind equine ACE2

Structure. 2022 Oct 6;30(10):1367-1368. doi: 10.1016/j.str.2022.09.003.

Authors

Philipp Nawrath¹, Antoni G Wrobel²

Affiliations

¹ Structural Biology of Disease Processes Laboratory, The Francis Crick Institute, London, UK.
² Structural Biology of Disease Processes Laboratory, The Francis Crick Institute, London, UK. Electronic address: [email protected].

Abstract

In this issue of Structure, Lan and colleagues seek to identify regions on the ACE2 receptor and coronavirus spikes that are essential for the viral attachment. They achieve it through a detailed comparative analysis of the binding of coronaviruses NL63, SARS-CoV, and several SARS-CoV-2 variants with human and horse ACE2.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Angiotensin-Converting Enzyme 2
Animals
COVID-19*
Coronavirus NL63, Human*
Horses
Humans
Peptidyl-Dipeptidase A / chemistry
Peptidyl-Dipeptidase A / metabolism
SARS-CoV-2

Hold your horses: The receptor-binding domains of SARS-CoV-2, SARS-CoV, and hCoV-NL63 bind equine ACE2

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

Supplementary concepts

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