Abstrct: Metabonomics is a relative discipline that develops after genomics and proteomics, and it is an important component of systems biology. It uses high-throughput and high-sensitivity instruments to perform qualitative and quantitative analysis of all metabolic components in specific biological samples under limited conditions and combines with multivariate statistics to analyze and process the data to obtain information about physiological, pathological or toxicological changes in organisms. In recent years, because of the complicated mechanism of substance abuse and the continuous emergence of new psychoactive substances, metabonomics is increasingly used in substance abuse research. Therefore, this article reviews the application of metabonomics of substance abuse in the toxic mechanism, the mechanism of addiction and the discovery of biomarkers.
代谢组学是继基因组学和蛋白质组学之后新近发展起来的一门学科，是系统生物学的重要组成部分，通过高通量、高灵敏度的仪器对限定条件下的特定生物样品中所有代谢组分进行定性定量分析，并结合多元统计对数据分析处理，获得机体生理、病理或毒理变化的信息。近年来，由于滥用物质的作用机制比较复杂，且新精神活性物质不断涌现，代谢组学在滥用物质中的研究越来越广泛。因此，本文对代谢组学在滥用物质毒性作用机制、成瘾机制及生物标志物的发现等方面的应用进行了综述。.
Keywords: biomarkers; forensic toxicology; metabonomics; review; substance abuse; toxic mechanisms.