Metabolic communication in the tumour-immune microenvironment

Kung-Chi Kao; Stefania Vilbois; Chin-Hsien Tsai; Ping-Chih Ho

doi:10.1038/s41556-022-01002-x

Metabolic communication in the tumour-immune microenvironment

Nat Cell Biol. 2022 Nov;24(11):1574-1583. doi: 10.1038/s41556-022-01002-x. Epub 2022 Oct 13.

Authors

Kung-Chi Kao^{1

2}, Stefania Vilbois^{1

2}, Chin-Hsien Tsai³, Ping-Chih Ho^{4

5}

Affiliations

¹ Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland.
² Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland.
³ Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan. [email protected].
⁴ Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland. [email protected].
⁵ Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland. [email protected].

PMID: 36229606
DOI: 10.1038/s41556-022-01002-x

Abstract

The metabolically hostile tumour microenvironment imposes barriers to tumour-infiltrating immune cells and impedes durable clinical remission following immunotherapy. Metabolic communication between cancer cells and their neighbouring immune cells could determine the amplitude and type of immune responses, highlighting a potential involvement of metabolic crosstalk in immune surveillance and escape. In this Review, we explore tumour-immune metabolic crosstalk and discuss potential nutrient-limiting strategies that favour anti-tumour immune responses.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Immunity
Immunotherapy
Neoplasms* / metabolism
Tumor Microenvironment*