SnapShot: Cancer immunoediting

Siva Karthik Varanasi; Susan M Kaech; Jack D Bui

doi:10.1016/j.cell.2022.09.027

SnapShot: Cancer immunoediting

Cell. 2022 Oct 13;185(21):4038-4038.e1. doi: 10.1016/j.cell.2022.09.027.

Authors

Siva Karthik Varanasi¹, Susan M Kaech¹, Jack D Bui²

Affiliations

¹ The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
² University of California, San Diego, La Jolla, CA 92093, USA.

PMID: 36240741
DOI: 10.1016/j.cell.2022.09.027

Abstract

In the tumor microenvironment, immune cells and tumor cells interact in a process called cancer immunoediting, giving rise to changes in gene expression, metabolism, mutational burden, and cellularity in the tumor. This SnapShot compares endogenous versus therapy-induced cancer immunoediting and outlines the molecular and cellular characteristics of interactions that result in complete tumor regression versus tumor escape and progression. To view this SnapShot, open or download the PDF.

MeSH terms

Humans
Mutation
Neoplasms / genetics
Neoplasms / immunology*
Neoplasms / therapy
Tumor Escape
Tumor Microenvironment*