Fracture-related infections (FRI) is a challenging complication with a high risk of devastation outcomes for the patients. Diagnosing FRI is often difficult, and treatment frequently requires the effort of a multidisciplinary team. Recently, an international consensus group of experts from various scientific and medical organisations has published standardised guidelines of diagnosis and treatment. This review provides a summary of the latest studies and the general principles with respect to diagnosis, treatment and aftercare of patients with FRI.