Bilateral Atypical Optic Neuritis following ChAdOx1_nCoV-19 Vaccination: A Putative Plausibility

Ocul Immunol Inflamm. 2023 Aug;31(6):1250-1253. doi: 10.1080/09273948.2022.2137044. Epub 2022 Oct 18.

Abstract

Purpose: In this case report, we describe the clinical features and treatment outcomes of bilateral optic neuritis developing after the administration of the first dose ChAdOx1_nCoV-19 (Covishield) vaccine in a previously healthy young immunocompetent male.

Study design: Case report.

Results: A 35-year-old healthy male, presented with sudden decrease in vision which was progressive in nature. The symptoms developed two days following the first dose of the Covid ChAdOx1_nCoV-19 vaccine. A possible diagnosis of vaccine associated optic neuritis was based on the temporal association between the administration of vaccine and the development of ocular symptoms and ruling out other immune or infectious etiologies. The patient showed good response to pulse systemic steroids followed by a short course of oral steroids.

Conclusion: Bilateral optic nerve involvement with disc edema may represent a rare adverse event of covid 19 vaccine which responds well to a short course of steroids.

Keywords: Covid 19; SARS CoV-2; covid 19 vaccine; neuro ophthalmic complications; optic neuritis; vaccines.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • COVID-19 Vaccines* / adverse effects
  • COVID-19* / prevention & control
  • ChAdOx1 nCoV-19
  • Humans
  • Male
  • Optic Neuritis* / diagnosis
  • Optic Neuritis* / etiology
  • Steroids
  • Vaccination / adverse effects

Substances

  • ChAdOx1 nCoV-19
  • COVID-19 Vaccines
  • Steroids