Ovarian Mature Cystic Teratoma is an Independent Risk Factor for the Premature Rupture of Membranes in Pregnancy: A Single-Center Retrospective Study

Yaru Sheng; Jiangjing Yuan; Jing Wang; Liya Wang; Yuhong Li; Yudong Wang

doi:10.2147/IJWH.S381297

Ovarian Mature Cystic Teratoma is an Independent Risk Factor for the Premature Rupture of Membranes in Pregnancy: A Single-Center Retrospective Study

Int J Womens Health. 2022 Oct 17:14:1477-1487. doi: 10.2147/IJWH.S381297. eCollection 2022.

Authors

Yaru Sheng¹, Jiangjing Yuan¹, Jing Wang¹, Liya Wang¹, Yuhong Li¹, Yudong Wang^{1

2

3}

Affiliations

¹ Department of Gynecologic Oncology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
² Shanghai Municipal Key Clinical Specialty, Female Tumor Reproductive Specialty, Shanghai, People's Republic of China.
³ Shanghai Key Laboratory of Embryo Original Disease, Shanghai, People's Republic of China.

Abstract

Background: Ovarian mature cystic teratomas (MCTs) are the most common tumors in pregnant women. The premature rupture of membranes (PROM) is a typical complication of pregnancy; however, the relationship between MCT and PROM is unknown. Therefore, we aimed to determine whether MCT is associated with the occurrence of PROM during pregnancy.

Methods: The data of patients with adnexal masses during pregnancy between January 2017 and August 2021 were retrospectively analyzed. Ovarian cystectomy was performed during cesarean delivery or after vaginal delivery. Univariate and multivariate logistic regression models were used for statistical analysis.

Results: A total of 234 patients with histopathological results were included. Among these patients, 21 occurred PROM during pregnancy, of which 11 were diagnosed with MCT. Compared with other subtypes, MCT (p=0.025) showed a stronger correlation with PROM and was an independent risk factor for PROM (odds ratio [OR], 2.811; 95% confidence interval [CI], 1.096-7.215; p=0.032). Furthermore, we found that MCT with a diameter >5 cm (p=0.0037) was more likely to promote the development of PROM than those that with a diameter <5 cm.

Conclusion: MCT was an independent risk factor for PROM during pregnancy. Positive actions and preventative clinical treatments should be fully taken into consideration by clinicians for pregnant women with MCTs, especially those ≥5 cm in diameter, to reduce the clinical complications related to MCT-associated PROM.

Keywords: benign ovarian tumor; mature cystic teratoma; pregnancy; premature rupture of membranes.

Grants and funding

This work was supported by Shanghai Municipal Key Clinical Specialty (No. shslczdzk06302), “Science and Technology Innovation Action Plan” International Science and Technology Cooperation Project (No. 20550760600), Clinical Technology Innovation Project of Shanghai Shenkang Hospital Development Center (No. SHDC12020130), Joint research projects of Xuhui Health Commission for critical diseases (XHLHGG202111), Shanghai Jiao Tong University Medicine-Engineering Fund (No. YG2022ZD027), National Natural Science Foundation of China (No. 81172477, 81402135), Shanghai Jiao Tong University School of Medicine, multi-center clinical research project (No. DLY201827).