Cell biology: Keeping the epithelium together when your neighbor divides

Maik C Bischoff; Mark Peifer

doi:10.1016/j.cub.2022.08.074

Cell biology: Keeping the epithelium together when your neighbor divides

Curr Biol. 2022 Oct 24;32(20):R1025-R1027. doi: 10.1016/j.cub.2022.08.074.

Authors

Maik C Bischoff¹, Mark Peifer²

Affiliations

¹ Department of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA.
² Department of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: [email protected].

PMID: 36283349
DOI: 10.1016/j.cub.2022.08.074

Abstract

The dramatic cell-shape changes involved in mitosis and cell division challenge the integrity of epithelial tissues. A new study reveals a surprising role for atypical protein kinase C in keeping apical contractility in balance and thus preventing epithelial disruption.

MeSH terms

Cell Shape
Epithelial Cells* / metabolism
Epithelium / metabolism
Mitosis*