Pd(0)/Blue Light Promoted Carboiodination Reaction - Evidence for Reversible C-I Bond Formation via a Radical Pathway

J Am Chem Soc. 2022 Nov 16;144(45):20554-20560. doi: 10.1021/jacs.2c09716. Epub 2022 Oct 28.

Abstract

A Pd(0)/blue light catalyzed carboiodination reaction is reported. A simple, air-stable catalytic system, utilizing [Pd(allyl)Cl]2 and DPEPhos, generated a variety of iodinated hetero- and carbocycles including oxindoles, dihydrobenzofurans, indolines, a chromane, and a tetrahydronaphthalene. This protocol was tolerant of sensitive functional groups including free carboxylic acids, phenols, and anilines, as well as pyridines, while delivering products in up to 94% yield. Support for a reversible C-I bond formation via a single electron mechanism was obtained using a deuterium labeled substrate and a stoichiometric neopentylpalladium species.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carboxylic Acids*
  • Catalysis
  • Light*

Substances

  • Carboxylic Acids