Keywords: Age-related macular degeneration (AMD); Aging; Alzheimer’s disease (AD) and related dementias; Astrocytes; Axon; Biomarker; Blood brain barrier (BBB); Blood retina barrier (BRB); Cellular senescence; Cerebral amyloid angiopathy (CAA); Electrophysiology; Endothelial cells; Genetic; Glaucoma; Hippocampal atrophy; Imaging; Inflammation; Inter-pericyte tunneling nanotubes (IP-TNT); Intraocular pressure; Ischemic; Maintenance; Microglia; Neurodegeneration; Neurovascular unit; Pericytes; Retinal ganglion cells (RGC); Skeletal cells; Stroke; Thrombosis; Vascular cognitive impairment and dementia (VCID); Vascular contributions; Vasoconstriction; Vasodilation.