Carcinoembryonic antigen (CEA) and two crossreacting antigens of 165 kD and 105 kD isolated from meconium exhibit identical amino terminal sequences

Biochem Biophys Res Commun. 1987 Aug 31;147(1):212-8. doi: 10.1016/s0006-291x(87)80108-0.

Abstract

Two antigens of 165 kD and 105 kD crossreacting with the carcinoembryonic antigen (CEA) were isolated from human meconium by perchloric acid extraction, differential immunoaffinity chromatography, and size exclusion HPLC. The sequences of the 30 amino terminal amino acids of both antigens are identical with the corresponding sequence of CEA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Antigens, Neoplasm*
  • Carcinoembryonic Antigen* / immunology
  • Carcinoembryonic Antigen* / isolation & purification
  • Cell Adhesion Molecules*
  • Cross Reactions
  • Glycoproteins* / immunology
  • Glycoproteins* / isolation & purification
  • Humans
  • Meconium / immunology*
  • Molecular Weight

Substances

  • Antigens, Neoplasm
  • Carcinoembryonic Antigen
  • Cell Adhesion Molecules
  • Glycoproteins