Positive association between triglyceride glucose index and central systolic blood pressure among hypertensive adults

Li Wang; Tian-Yu Cao; Jin-Qiao Li; Cong-Cong Ding; Jun-Pei Li; Hua-Bo Ying; Li-Shun Liu; Xiao Huang

doi:10.11909/j.issn.1671-5411.2022.10.006

Positive association between triglyceride glucose index and central systolic blood pressure among hypertensive adults

J Geriatr Cardiol. 2022 Oct 28;19(10):753-760. doi: 10.11909/j.issn.1671-5411.2022.10.006.

Authors

Li Wang¹, Tian-Yu Cao², Jin-Qiao Li³, Cong-Cong Ding⁴, Jun-Pei Li⁴, Hua-Bo Ying⁴, Li-Shun Liu^{5

6

7}, Xiao Huang⁴

Affiliations

¹ Department of Nephrology, the Fourth Hospital of Harbin Medical University, Harbin, China.
² Biological Anthropology, University of California Santa Barbara, California, USA.
³ Department of Urology Surgery, Graduate School of the Fourth Hospital of Harbin Medical University, Harbin, China.
⁴ Department of Cardiology, the Second Affiliated Hospital of Nanchang University, Nanchang, China.
⁵ Institute of Biomedicine, Anhui Medical University, Hefei, China.
⁶ Institute of Biomedical and Health Engineering, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China.
⁷ Shenzhen Evergreen Medical Institute, Shenzhen, China.

PMID: 36338286
PMCID: PMC9618843
DOI: 10.11909/j.issn.1671-5411.2022.10.006

Abstract

Background: While studies have suggested the association between triglyceride-glucose (TyG) index, a reliable surrogate for insulin resistance and hypertension data are limited to the correlation of TyG and central blood pressure. This study aims to test the hypothesis that a higher TyG index is associated with elevated central systolic blood pressure (cSBP).

Methods: A total of 9249 Chinese hypertensive adults from the H-type Hypertension and Stroke Prevention and Control Project were analyzed in this study. cSBP was measured noninvasively using an A-Pulse CASPro device. TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Smoothing curve and multivariate linear regression models [beta coefficient (β) with 95% CI] were applied to analyze the association between TyG index and cSBP. Subgroup analyses were conducted to explore potential modifications to such a correlation.

Results: The overall mean TyG index is 8.8 ± 0.7, and the total mean cSBP is 131.3 ± 12.8 mmHg. TyG index was observed to be independently and positively associated with cSBP among the total population (β = 0.92, 95% CI: 0.53-1.31, P < 0.001), and participants who do not use antihypertensive drugs (β = 1.03, 95% CI: 0.46-1.60, P < 0.001), which is in accordance with the result of the smoothing curve. The association between TyG index and cSBP appears robust in all tested subgroups.

Conclusions: TyG index is positively and independently associated with cSBP among hypertensive adults. Our study result suggests that TyG index might serve as an effective marker for vascular function.