Construction of diverse polycyclic N-heterocycles via cascade allylic amination/Diels-Alder reaction

Chem Commun (Camb). 2022 Nov 29;58(95):13258-13261. doi: 10.1039/d2cc05208c.

Abstract

An efficient cascade approach for the construction of nitrogen-containing polycyclic compounds from amines tethered with an alkenyl (or alkynyl) group and divinyl carbonates is described. In the presence of Pd(0)-catalyst, an active zwitterionic allylpalladium species is generated and undergoes allylic amination with various amines followed by Diels-Alder reaction to form various polycyclic N-heterocyclic products, including hydrophenanthridines, hydrobenzo[c]azepines (hydro)isoindoles and hydrobenzo[cd]indoles.

MeSH terms

  • Amination
  • Amines*
  • Catalysis
  • Cycloaddition Reaction
  • Molecular Structure

Substances

  • Amines