Cytotoxic flavonoids from the leaves of Callicarpa nudiflora hook

Nat Prod Res. 2024 Apr;38(8):1435-1440. doi: 10.1080/14786419.2022.2144295. Epub 2022 Nov 12.

Abstract

A new flavonoid glycoside, luteolin-3'-O-β-D-6″-acetyl glucopyranoside (1), along with six known flavonoids, were isolated from the leaves of Callicarpa nudiflora Hook. The structures of the isolated compounds were established on the basis of extensive spectroscopic analyses. Compound 6 exhibited potent cytotoxicity and compounds 1 and 7 exhibited moderate cytotoxicity against human hepatocellular carcinoma SMMC-7721 cells.

Keywords: Callicarpa nudiflora Hook; cytotoxicity; hepatocellular carcinoma; luteolin-3′-O-β-D-6″-acetyl glucopyranoside; pachypodol.

MeSH terms

  • Antineoplastic Agents*
  • Callicarpa* / chemistry
  • Cell Line
  • Flavonoids / pharmacology
  • Humans
  • Molecular Structure
  • Spectrum Analysis

Substances

  • Flavonoids
  • Antineoplastic Agents