The remarkable regenerative capability of the liver has long been appreciated. Upon significant loss of liver tissue, the remnant liver can grow rapidly to restore the original liver mass through a combination of hepatocyte proliferation and hypertrophy to maintain homeostasis. Experimentally, 2/3 partial hepatectomy in mice has been used extensively as a model to dissect the molecular mechanism of liver regeneration and the genetic networks involved. Herein, we describe the protocols for partial hepatectomy and analyses of pertinent CCN protein functions.
Keywords: Liver; Partial hepatectomy; Proliferation; Regeneration; Senescence; Surgery.
© 2023. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.