Intraparenchymal metastases as a cause for local recurrence of pancreatic cancer

Ashley L Kiemen; YoungGeun Choi; Alicia M Braxton; Cristina Almagro Pérez; Sarah Graham; Mia P Grahn; Neha Nanda; Nicholas Roberts; Laura Wood; PeiHsun Wu; Ralph H Hruban; Denis Wirtz

doi:10.1111/his.14839

Intraparenchymal metastases as a cause for local recurrence of pancreatic cancer

Histopathology. 2023 Feb;82(3):504-506. doi: 10.1111/his.14839. Epub 2022 Nov 21.

Authors

Ashley L Kiemen^{1

2

3}, YoungGeun Choi⁴, Alicia M Braxton¹, Cristina Almagro Pérez⁴, Sarah Graham¹, Mia P Grahn², Neha Nanda¹, Nicholas Roberts¹, Laura Wood^{1

3}, PeiHsun Wu², Ralph H Hruban^{1

3}, Denis Wirtz^{1

2

3

5}

Affiliations

¹ Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
² Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD, USA.
³ Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
⁴ Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA.
⁵ Department of Materials Science and Engineering, The Johns Hopkins University, Baltimore, MD, USA.

Abstract

Using CODA, a technique for three-dimensional reconstruction of large tissues, Kiemen et al. report observation of a microscopic focus of pancreatic cancer found in the vasculature of grossly normal human pancreas tissue resected adjacent to a large tumour. They use TP53 and SMAD4 staining to relate the small focus to the primary tumour. This report describes a represents a probable case of intraparenchymal metastasis of pancreatic cancer, revealing a probable cause of local recurrence.

Intraparenchymal metastases as a cause for local recurrence of pancreatic cancer

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