To kill or not to kill - The role of the tumor microenvironment in shaping group 1 ILC functions

Nils Christian Müller; Chiara Romagnani

doi:10.1016/j.smim.2022.101670

To kill or not to kill - The role of the tumor microenvironment in shaping group 1 ILC functions

Semin Immunol. 2022 Nov:61-64:101670. doi: 10.1016/j.smim.2022.101670. Epub 2022 Nov 10.

Authors

Nils Christian Müller¹, Chiara Romagnani²

Affiliations

¹ Innate Immunity, German Rheumatism Research Center (DRFZ), Leibniz Association, Virchhowweg 12, 10117 Berlin, Germany.
² Innate Immunity, German Rheumatism Research Center (DRFZ), Leibniz Association, Virchhowweg 12, 10117 Berlin, Germany; Department for Gastroenterology, Infectious diseases, Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Campus Benjamin Franklin, Berlin, Germany. Electronic address: [email protected].

Abstract

Group 1 innate lymphoid cells (ILC) comprise two major IFN-γ producing populations, namely Natural Killer (NK) cells, and ILC1s. Recent studies have revealed a complex and diverse composition of group 1 ILC subsets infiltrating different tumors. In this review, we will outline the commonalities and differences between group 1 ILC subsets in both mice and humans, discuss how the tissue and tumor microenvironment shapes their phenotype and functions, as well as describe their contrasting roles in the response to different cancers.

Keywords: Cancer; IL-15; ILC1; NK cells; TGF-β; Tumor microenvironment.

Publication types

Review

MeSH terms

Animals
Humans
Immunity, Innate
Killer Cells, Natural
Lymphocytes / pathology
Mice
Neoplasms* / pathology
Tumor Microenvironment*

Grants and funding

101055157/ERC_/European Research Council/International