Maternal care of the whole litter improves the success rate of diabetes in pregnancy in rats

Juliana Ferreira Floriano; Angélica Mércia Pascon Barbosa; Rafael Guilen de Oliveira; Sofía Vega; Bruna Bologna Catinelli; Gabriela Azevedo Garcia; David Rafael Reyes; Luis Sobrevia; Marilza Vieira Cunha Rudge; DIAMATER Study Group

doi:10.1016/j.placenta.2022.11.002

Maternal care of the whole litter improves the success rate of diabetes in pregnancy in rats

Placenta. 2022 Dec:130:42-45. doi: 10.1016/j.placenta.2022.11.002. Epub 2022 Nov 7.

Authors

Juliana Ferreira Floriano¹, Angélica Mércia Pascon Barbosa², Rafael Guilen de Oliveira³, Sofía Vega⁴, Bruna Bologna Catinelli⁵, Gabriela Azevedo Garcia³, David Rafael Reyes³, Luis Sobrevia⁶, Marilza Vieira Cunha Rudge⁷; DIAMATER Study Group

Affiliations

¹ São Paulo State University (UNESP), Botucatu Medical School, Botucatu, São Paulo, Brazil; National Heart and Lung Institute, Imperial College London, London, UK. Electronic address: [email protected].
² São Paulo State University (UNESP), Botucatu Medical School, Botucatu, São Paulo, Brazil; Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile; São Paulo State University (UNESP), School of Philosophy and Sciences, Marília, São Paulo, Brazil.
³ São Paulo State University (UNESP), Botucatu Medical School, Botucatu, São Paulo, Brazil.
⁴ São Paulo State University (UNESP), Botucatu Medical School, Botucatu, São Paulo, Brazil; Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
⁵ São Paulo State University (UNESP), Botucatu Medical School, Botucatu, São Paulo, Brazil; São Paulo State University (UNESP), School of Philosophy and Sciences, Marília, São Paulo, Brazil.
⁶ São Paulo State University (UNESP), Botucatu Medical School, Botucatu, São Paulo, Brazil; Cellular and Molecular Physiology Laboratory (CMPL), Department of Obstetrics, Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile; Department of Physiology, Faculty of Pharmacy, Universidad de Sevilla, Seville, Spain; University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine and Biomedical Sciences, University of Queensland, Herston, Queensland, Australia; Tecnologico de Monterrey, Eutra, The Institute for Obesity Research, School of Medicine and Health Sciences, Monterrey, Nuevo León, Mexico. Electronic address: [email protected].
⁷ São Paulo State University (UNESP), Botucatu Medical School, Botucatu, São Paulo, Brazil. Electronic address: [email protected].

PMID: 36375223
DOI: 10.1016/j.placenta.2022.11.002

Abstract

Induction of diabetes mellitus by streptozotocin (STZ) in rats at birth is of high mortality and low success rate when male puppies are separated from females, prioritizing females breastfeeding. Cross-parental care of the entire litter and SZT-induced diabetes up to 12 h post-birth become with high success rate, low animal death, and females with glycaemia >140 mg/dL on the 90 postnatal day. Cross-parental care is more effective in STZ-induction of diabetes, which is maintained during pregnancy (diabetes in pregnancy), than the conventional protocol of male separation at birth.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Glucose*
Diabetes Mellitus, Experimental* / therapy
Dogs
Female
Male
Pregnancy
Rats
Streptozocin / adverse effects

Substances

Streptozocin
Blood Glucose