Noninvasive approaches to detect methylation-based markers to monitor gliomas

Houtan Noushmehr; Grayson Herrgott; Natalia S Morosini; Ana Valeria Castro

doi:10.1093/noajnl/vdac021

Noninvasive approaches to detect methylation-based markers to monitor gliomas

Neurooncol Adv. 2022 Nov 11;4(Suppl 2):ii22-ii32. doi: 10.1093/noajnl/vdac021. eCollection 2022 Nov.

Authors

Houtan Noushmehr¹, Grayson Herrgott¹, Natalia S Morosini¹, Ana Valeria Castro¹

Affiliation

¹ Department of Neurosurgery, Omics Laboratory, Henry Ford Health System, Detroit, Michigan, USA.

Abstract

In this review, we summarize the current approaches used to detect glioma tissue-derived DNA methylation markers in liquid biopsy specimens with the aim to diagnose, prognosticate and potentially track treatment response and evolution of patients with gliomas.

Keywords: epigenetics; glioma; liquid biopsy; machine-learning; non-invasive biomarkers.