ZnO nanoparticle modified chitosan/borosilicate bioglass composite scaffold for inhibiting bacterial infection and promoting bone regeneration

Dewei Qiu; Ping Zhou; Jiawei Kang; Zhijun Chen; Zhiyong Xu; Hanwen Yang; Jun Tao; Fanrong Ai

doi:10.1088/1748-605X/ac99c5

ZnO nanoparticle modified chitosan/borosilicate bioglass composite scaffold for inhibiting bacterial infection and promoting bone regeneration

Biomed Mater. 2022 Nov 17;17(6). doi: 10.1088/1748-605X/ac99c5.

Authors

Dewei Qiu¹, Ping Zhou¹, Jiawei Kang¹, Zhijun Chen¹, Zhiyong Xu², Hanwen Yang², Jun Tao¹, Fanrong Ai²

Affiliations

¹ Department of Orthopedic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, People's Republic of China.
² School of Advanced Manufacturing, Nanchang University, Nanchang, Jiangxi 330031, People's Republic of China.

PMID: 36394277
DOI: 10.1088/1748-605X/ac99c5

Abstract

The treatment of implant-associated bone infection remains a significant clinical challenge. However, bone scaffolds with antimicrobial activity and osteoinductive properties can prevent these infections and improve clinical outcomes. In this study, borosilicate bioglass and chitosan composite scaffolds were prepared, and then the surface was modified with nano-zinc oxide.In vitroandin vivoexperiments showed that the chitosan/borosilicate bioglass scaffolds have good degradation and osteogenic properties, while the oxidized Zinc scaffolds have better antibacterial properties.

Keywords: ZnO nanoparticles; borosilicate bioglass; chitosan; infection; surface multifunction.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Infections*
Bone Regeneration
Chitosan*
Humans
Tissue Engineering
Tissue Scaffolds
Zinc Oxide*

Substances

Chitosan
Bioglass
Zinc Oxide