Computed tomography imaging for subclinical leaflet thrombosis following surgical and transcatheter aortic valve replacement

Hashrul N Rashid; Ronak Rajani; Jonathon Leipsic; Pál Maurovitch-Horvat; Tiffany Patterson; Simon Redwood; Jack Lee; Harriet Hurrell; Stephen J Nicholls; Arthur Nasis; Sujith Seneviratne; James D Cameron; Bernard Prendergast; Robert P Gooley

doi:10.1016/j.jcct.2022.11.001

Computed tomography imaging for subclinical leaflet thrombosis following surgical and transcatheter aortic valve replacement

J Cardiovasc Comput Tomogr. 2023 Jan-Feb;17(1):2-10. doi: 10.1016/j.jcct.2022.11.001. Epub 2022 Nov 8.

Authors

Affiliations

¹ MonashHeart, Monash Health and Monash Cardiovascular Research Centre, Monash University, Melbourne, Australia; Department of Cardiology, Guy's & St. Thomas' Hospital, London, United Kingdom. Electronic address: [email protected].
² Department of Cardiology, Guy's & St. Thomas' Hospital, London, United Kingdom. Electronic address: [email protected].
³ Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: [email protected].
⁴ MTA-SE Cardiovascular Imaging Research Group, Medical Imaging Centre, Semmelweis University, Budapest, Hungary. Electronic address: [email protected].
⁵ Department of Cardiology, Guy's & St. Thomas' Hospital, London, United Kingdom; School of Cardiovascular Medicine & Sciences, King's College London, London, United Kingdom. Electronic address: [email protected].
⁶ Department of Cardiology, Guy's & St. Thomas' Hospital, London, United Kingdom; School of Cardiovascular Medicine & Sciences, King's College London, London, United Kingdom. Electronic address: [email protected].
⁷ Biomedical Engineering Department, King's College London, London, United Kingdom. Electronic address: [email protected].
⁸ Department of Cardiology, Guy's & St. Thomas' Hospital, London, United Kingdom; School of Cardiovascular Medicine & Sciences, King's College London, London, United Kingdom. Electronic address: [email protected].
⁹ MonashHeart, Monash Health and Monash Cardiovascular Research Centre, Monash University, Melbourne, Australia. Electronic address: [email protected].
¹⁰ MonashHeart, Monash Health and Monash Cardiovascular Research Centre, Monash University, Melbourne, Australia. Electronic address: [email protected].
¹¹ MonashHeart, Monash Health and Monash Cardiovascular Research Centre, Monash University, Melbourne, Australia. Electronic address: [email protected].
¹² MonashHeart, Monash Health and Monash Cardiovascular Research Centre, Monash University, Melbourne, Australia. Electronic address: [email protected].
¹³ Department of Cardiology, Guy's & St. Thomas' Hospital, London, United Kingdom. Electronic address: [email protected].
¹⁴ MonashHeart, Monash Health and Monash Cardiovascular Research Centre, Monash University, Melbourne, Australia. Electronic address: [email protected].

PMID: 36396555
DOI: 10.1016/j.jcct.2022.11.001

Abstract

Subclinical leaflet thrombosis (LT) may occur following surgical and transcatheter aortic valve replacement. Computed tomography (CT) has become an established imaging modality to diagnose subclinical LT following bioprosthetic aortic valve replacement. Even so, there is a limited (but growing) experience in utilizing CT imaging for this indication. This review emphasizes a systematic approach to acquiring and analysing CT imaging for subclinical LT, highlighting evidence surrounding clinical sequelae of subclinical LT and anti-thrombotic implications following diagnosis.

Keywords: Aortic stenosis; Aortic valve replacement; Computed tomography; Leaflet thrombosis; TAVR.

Publication types

Review

MeSH terms

Aortic Valve / surgery
Aortic Valve Stenosis* / surgery
Heart Valve Prosthesis*
Humans
Predictive Value of Tests
Risk Factors
Thrombosis* / surgery
Tomography, X-Ray Computed
Transcatheter Aortic Valve Replacement* / methods
Treatment Outcome