Post-Transfusion Simultaneous Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndrome: A Rare Occurrence

Cureus. 2022 Oct 11;14(10):e30181. doi: 10.7759/cureus.30181. eCollection 2022 Oct.

Abstract

Endothelial cell injury, intravascular platelet-fibrin thrombi, and vascular damage are found in hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). The two disorders frequently manifest independently and are the important causes of acute renal damage. Acute kidney injury developed in our patient after blood transfusion and later on, the patient developed neurological complications. The patient was managed symptomatically and conservatively. Plasmapheresis and corticosteroid administration showed improved results.

Keywords: acute kidney injury; endothelial; intravascular; plasmapheresis; thrombi.

Publication types

  • Case Reports