Facile construction of dibenzodioxo[3.3.1]nonanes bearing spirocyclohexadienones via domino [4 + 2] cycloaddition/C(sp3)-H oxidative dehydrogenation coupling reactions

Org Biomol Chem. 2022 Dec 7;20(47):9392-9396. doi: 10.1039/d2ob01860h.

Abstract

A novel palladium catalyzed homodimerization of ortho-hydroxyphenyl substituted p-QMs has been developed via [4 + 2] cycloaddition/oxidative dehydrogenation coupling domino reactions. An interesting palladium catalyzed intramolecular benzyl C-H oxidation dehydrogenation to form a transannular C(sp3)-O bond was found. This protocol provided an efficient method to construct various dibenzodioxo[3.3.1]nonanes bearing spirocyclohexadienones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Palladium*

Substances

  • Palladium