Secondhand smoke exposure is independently associated with stroke among non-smoking adults in West Africa

Akinkunmi Paul Okekunle; Osahon Jeffery Asowata; Adekunle G Fakunle; Onoja Matthew Akpa; Fred S Sarfo; Albert Akpalu; Kolawole Wahab; Reginald Obiako; Morenikeji Komolafe; Lukman Owolabi; Godwin O Osaigbovo; Hemant K Tiwari; Joshua Akinyemi; Carolyn Jenkins; Oyedunni Arulogun; Philip Ibinaiye; Lambert Appiah; Atinuke M Agunloye; Abiodun M Adeoye; Joseph Yaria; Benedict Calys-Tagoe; Ezinne O Uvere; Godwin Ogbole; Francis Agyekum; Taofeek A Sanni; Ganiyu A Amusa; Mayowa Ogunronbi; Samuel Olowookere; Olayemi Balogun; James A Ogunmodede; Oladotun V Olalusi; Diala Samuel; Aliyu Mande; Musbahu Rabiu; Philip Adebayo; Adeniyi Sunday; Lucius Chidiebere Imoh; Ayodipupo S Oguntade; Abiodun Ajose; Arti Singh; Oluwayemisi T Adeegbe; Yaw Mensah; Michael B Fawale; Salaam Abdul; Joyce Ikubor; Afolaranmi Tolulope; Isah S Yahaya; Cynthia Akisanya; Chidi J Odo; Richard Efidi; Innocent I Chukwuonye; Vincent Shidali; Akintunde Adebowale; Kenneth A Ohagwu; Osimhiarherhuo O Adeleye; Henry Iheonye; Adeseye Akintunde; Eunice Olabinri; Josephine Akpalu; Julius Adesina; Ugochukwu Onyeonoro; Akinola Onasanya; Donna K Arnett; Daniel Lackland; Rufus Akinyemi; Bruce Ovbiagele; Mayowa Owolabi; SIREN

doi:10.1016/j.jns.2022.120489

Secondhand smoke exposure is independently associated with stroke among non-smoking adults in West Africa

J Neurol Sci. 2022 Dec 15:443:120489. doi: 10.1016/j.jns.2022.120489. Epub 2022 Nov 8.

Authors

Akinkunmi Paul Okekunle¹, Osahon Jeffery Asowata², Adekunle G Fakunle³, Onoja Matthew Akpa⁴, Fred S Sarfo⁵, Albert Akpalu⁶, Kolawole Wahab⁷, Reginald Obiako⁸, Morenikeji Komolafe⁹, Lukman Owolabi¹⁰, Godwin O Osaigbovo¹¹, Hemant K Tiwari¹², Joshua Akinyemi², Carolyn Jenkins¹³, Oyedunni Arulogun¹⁴, Philip Ibinaiye⁸, Lambert Appiah⁵, Atinuke M Agunloye¹⁵, Abiodun M Adeoye¹⁶, Joseph Yaria¹⁷, Benedict Calys-Tagoe⁶, Ezinne O Uvere¹⁷, Godwin Ogbole¹⁵, Francis Agyekum⁶, Taofeek A Sanni¹⁸, Ganiyu A Amusa¹¹, Mayowa Ogunronbi¹⁹, Samuel Olowookere¹⁹, Olayemi Balogun⁸, James A Ogunmodede⁷, Oladotun V Olalusi¹⁷, Diala Samuel¹⁷, Aliyu Mande¹⁰, Musbahu Rabiu¹⁰, Philip Adebayo²⁰, Adeniyi Sunday⁷, Lucius Chidiebere Imoh¹¹, Ayodipupo S Oguntade²¹, Abiodun Ajose¹⁷, Arti Singh⁵, Oluwayemisi T Adeegbe¹⁷, Yaw Mensah⁶, Michael B Fawale⁹, Salaam Abdul¹¹, Joyce Ikubor²², Afolaranmi Tolulope¹¹, Isah S Yahaya¹⁰, Cynthia Akisanya¹⁹, Chidi J Odo¹⁵, Richard Efidi²³, Innocent I Chukwuonye²⁴, Vincent Shidali²⁵, Akintunde Adebowale⁹, Kenneth A Ohagwu²⁴, Osimhiarherhuo O Adeleye¹⁹, Henry Iheonye²⁶, Adeseye Akintunde²⁷, Eunice Olabinri¹⁸, Josephine Akpalu⁶, Julius Adesina¹⁹, Ugochukwu Onyeonoro²⁴, Akinola Onasanya²⁸, Donna K Arnett²⁹, Daniel Lackland³⁰, Rufus Akinyemi³¹, Bruce Ovbiagele³², Mayowa Owolabi³³; SIREN

Affiliations

¹ Department of Medicine, University of Ibadan, Nigeria; Department of Food and Nutrition, Seoul National University, Republic of Korea. Electronic address: [email protected].
² Department of Epidemiology and Medical Statistics, University of Ibadan, Nigeria.
³ Department of Medicine, University of Ibadan, Nigeria; Department of Public Health, Osun State University, Osogbo, Nigeria.
⁴ Department of Epidemiology and Medical Statistics, University of Ibadan, Nigeria; Institute of Cardiovascular Diseases, University of Ibadan, Nigeria.
⁵ Kwame Nkrumah University of Science and Technology, Ghana.
⁶ Department of Medicine, University of Ghana Medical School, Accra, Ghana.
⁷ Department of Medicine, University of Ilorin, Ilorin, Nigeria.
⁸ Department of Medicine, Ahmadu Bello University, Zaria, Nigeria.
⁹ Obafemi Awolowo University, Ile-Ife, Nigeria.
¹⁰ Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria.
¹¹ Jos University Teaching Hospital Jos, Nigeria.
¹² University of Alabama at Birmingham, Birmingham, AL, USA.
¹³ Medical University of South Carolina, SC, USA.
¹⁴ Department of Health Promotion and Education, University of Ibadan, Nigeria.
¹⁵ Department of Radiology, University of Ibadan, Nigeria.
¹⁶ Department of Medicine, University of Ibadan, Nigeria; Institute of Cardiovascular Diseases, University of Ibadan, Nigeria; Center for Genomic and Precision Medicine, University of Ibadan, Nigeria.
¹⁷ Department of Medicine, University of Ibadan, Nigeria.
¹⁸ Federal Teaching Hospital, Ido-, Ekiti, Nigeria.
¹⁹ Federal Medical Centre, Abeokuta, Nigeria.
²⁰ Aga-Khan University Dar es Salaam, Tanzania.
²¹ Department of Medicine, University of Ibadan, Nigeria; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Big Data Institute, Oxford Population Health, University of Oxford, UK.
²² Delta State University Teaching Hospital, Oghara, Delta State, Nigeria.
²³ Department of Radiology, University College Hospital, Ibadan, Nigeria.
²⁴ Federal Medical Centre, Umuahia, Nigeria.
²⁵ Federal Medical Center, Keffi, Nigeria.
²⁶ Department of Medicine, Federal Medical Centre, Lokoja, Nigeria.
²⁷ Ladoke Akintola University of Technology/Teaching Hospital, Ogbomosho, Nigeria.
²⁸ Sacred Heart Hospital Lantoro, Abeokuta, Ogun State, Nigeria.
²⁹ University of South Carolina, Columbia, SC, USA.
³⁰ Department of Neurology, Medical University of South Carolina, USA.
³¹ Federal Medical Centre, Abeokuta, Nigeria; Center for Genomic and Precision Medicine, University of Ibadan, Nigeria; Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.
³² Weill Institute for Neurosciences, University of California San Francisco, USA.
³³ Department of Medicine, University of Ibadan, Nigeria; Center for Genomic and Precision Medicine, University of Ibadan, Nigeria. Electronic address: [email protected].

Abstract

Background: Stroke is a leading cause of disability and mortality worldwide, but little is known about the contribution of secondhand smoke exposure (SHSE) to stroke epidemiology among indigenous Africans.

Objective: To evaluate the association of SHSE with stroke among indigenous Africans.

Methods: We analyzed the relationship of SHSE with stroke among 2990 case-control pairs of adults who had never smoked (identified in the SIREN study) using conditional logistic regression at a two-sided P < 0.05.

Results: Multivariable-adjusted odds ratio and 95% confidence interval; 1.25 (1.04, 1.50; P = 0.02) revealed SHSE was positively associated with stroke independent of stroke subtypes.

Conclusion: Culturally relevant primary prevention strategies targeted at SHSE might be promising in preventing stroke among Africans.

Keywords: Haemorrhagic stroke; Ischaemic stroke; SIREN; Secondhand smoking; Stroke.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Adult
Africa, Western / epidemiology
Black People
Humans
Odds Ratio
Stroke* / epidemiology
Tobacco Smoke Pollution* / adverse effects

Substances

Tobacco Smoke Pollution

Abstract

Publication types

MeSH terms

Substances

Grants and funding