De novo natural anti-M alloantibody emergence in severe Coronavirus Disease 2019

Robin Jeannet; Alexandra Descazeaud; Thomas Daix; Hélène Pauthier; Virginie Pascal; Sébastien Hantz; Sophie Le Cam; Bruno Francois; Jean Feuillard; Xavier Lafarge

doi:10.1016/j.jiph.2022.10.025

De novo natural anti-M alloantibody emergence in severe Coronavirus Disease 2019

J Infect Public Health. 2022 Dec;15(12):1455-1458. doi: 10.1016/j.jiph.2022.10.025. Epub 2022 Nov 2.

Authors

Affiliations

¹ INSERM CIC 1435, CHU Dupuytren, and UMR CNRS 7276 INSERM 1262, Université de Limoges, Limoges, France. Electronic address: [email protected].
² Laboratoire d'Immunohématologie, Établissement Français du Sang Nouvelle-Aquitaine, Limoges, France. Electronic address: [email protected].
³ INSERM CIC 1435 and Réanimation polyvalente, CHU Dupuytren, and INSERM UMR 1092, Université de Limoges, Limoges, France. Electronic address: [email protected].
⁴ Laboratoire d'Immunohématologie, Établissement Français du Sang Nouvelle-Aquitaine, Limoges, France. Electronic address: [email protected].
⁵ UMR CNRS 7276, INSERM 1262, Université de Limoges, and Laboratoire d'Immunologie, CHU Dupuytren, Limoges, France. Electronic address: [email protected].
⁶ UMR INSERM 1092, RESINFIT, Université de Limoges, and Centre National de Référence des Herpèsvirus and Service de Bactériologie, Virologie et Hygiène, CHU Dupuytren, Limoges, France. Electronic address: [email protected].
⁷ Laboratoire de qualification biologique des dons, Établissement Français du Sang Centre-Pays de la Loire, Angers, France. Electronic address: [email protected].
⁸ INSERM CIC 1435 and Réanimation polyvalente, CHU Dupuytren, and INSERM UMR 1092, Université de Limoges, Limoges, France. Electronic address: [email protected].
⁹ UMR CNRS 7276 / INSERM 1262 CRIBL and Laboratoire d'Hématologie, Faculté de Médecine and CHU Dupuytren, Limoges, France. Electronic address: [email protected].
¹⁰ INSERM U1035 Biothérapie des Maladies Génétiques, Inflammatoires et Cancers, and Direction Médicale, Établissement Français du Sang Nouvelle-Aquitaine, Bordeaux, France. Electronic address: [email protected].

Abstract

The immune response is a key player in the course of SARS-CoV-2 infection, and is often seriously dysfunctional in severe Coronavirus Disease 2019. The hyperinflammatory status has been described to be accompanied by the appearance of autoantibodies. In a lethal COVID-19 infection, we observed the emergence of a de novo natural alloantibody which targeted the M antigen from the MNS blood group on red blood cells (RBC) without evidence of any cross-reaction with SARS-CoV-2 antigens. This IgM lambda alloantibody was unmutated and unswitched. Here, we describe for the first time the emergence of a bystander de novo natural alloantibody against RBCs in a severe COVID-19 patient, highlighting the extra-follicular humoral response reported in these cases.

Keywords: Alloantibody; COVID-19; M-antigen; Transfusion.

MeSH terms

Blood Group Antigens*
COVID-19*
Erythrocytes
Humans
SARS-CoV-2

Substances

Blood Group Antigens