The birth of Dolly and xenotransplantation 25 years on

Mark B Nottle; Wayne J Hawthorne; Peter J Cowan

doi:10.1111/xen.12782

The birth of Dolly and xenotransplantation 25 years on

Xenotransplantation. 2023 Jan;30(1):e12782. doi: 10.1111/xen.12782. Epub 2022 Nov 22.

Authors

Mark B Nottle¹, Wayne J Hawthorne^{2

3}, Peter J Cowan^{4

5}

Affiliations

¹ School of Biomedicine and Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
² The Centre for Transplant & Renal Research, Westmead Institute for Medical Research, Westmead, New South Wales, Australia.
³ Department of Surgery, Westmead Hospital, School of Medical Sciences, University of Sydney, Westmead, New South Wales, Australia.
⁴ Immunology Research Centre, St. Vincent's Hospital, Melbourne, Victoria, Australia.
⁵ Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.

PMID: 36413478
DOI: 10.1111/xen.12782

Abstract

A number of reviews have been written recently celebrating the 25th anniversary of the birth of Dolly the cloned sheep and the effect this breakthrough has had on various fields of research. However, arguably the biggest impact Dolly has had is on the field of xenotransplantation, described here based on our own experience and that of others.

Keywords: genetic modifcation; pig cloning; somatic cell nuclear transferr; transgenesis.

MeSH terms

Animals
Cloning, Organism*
Nuclear Transfer Techniques*
Sheep
Transplantation, Heterologous