Landscape of immunoglobulin heavy chain γ gene class switch recombination in patients with adult T-cell leukemia-lymphoma

Hiroaki Hiramatsu; Kisato Nosaka; Shigeru Kusumoto; Nobuaki Nakano; Ilseung Choi; Makoto Yoshimitsu; Yoshitaka Imaizumi; Michihiro Hidaka; Hidenori Sasaki; Junya Makiyama; Eiichi Ohtsuka; Tatsuro Jo; Masao Ogata; Asahi Ito; Kentaro Yonekura; Hiro Tatetsu; Takeharu Kato; Toshiro Kawakita; Youko Suehiro; Kenji Ishitsuka; Shinsuke Iida; Takaji Matsutani; Hiroyoshi Nishikawa; Atae Utsunomiya; Ryuzo Ueda; Takashi Ishida

doi:10.3324/haematol.2022.281435

Landscape of immunoglobulin heavy chain γ gene class switch recombination in patients with adult T-cell leukemia-lymphoma

Haematologica. 2023 Apr 1;108(4):1173-1178. doi: 10.3324/haematol.2022.281435.

Authors

Hiroaki Hiramatsu¹, Kisato Nosaka², Shigeru Kusumoto³, Nobuaki Nakano⁴, Ilseung Choi⁵, Makoto Yoshimitsu⁶, Yoshitaka Imaizumi⁷, Michihiro Hidaka⁸, Hidenori Sasaki⁹, Junya Makiyama¹⁰, Eiichi Ohtsuka¹¹, Tatsuro Jo¹², Masao Ogata¹³, Asahi Ito³, Kentaro Yonekura¹⁴, Hiro Tatetsu¹⁵, Takeharu Kato⁷, Toshiro Kawakita⁸, Youko Suehiro¹⁶, Kenji Ishitsuka⁶, Shinsuke Iida³, Takaji Matsutani¹⁷, Hiroyoshi Nishikawa¹, Atae Utsunomiya⁴, Ryuzo Ueda¹, Takashi Ishida¹⁸

Affiliations

¹ Department of Immunology, Nagoya University Graduate School of Medicine.
² Cancer Center, Kumamoto University Hospital.
³ Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences.
⁴ Department of Hematology, Imamura General Hospital.
⁵ Department of Hematology, National Hospital Organization Kyushu Cancer Centre Hospital.
⁶ Department of Hematology and Rheumatology, Kagoshima University Graduate School of Medical and Dental Sciences.
⁷ Department of Hematology, Nagasaki University Hospital.
⁸ Department of Hematology, National Hospital Organization Kumamoto Medical Center.
⁹ Division of Medical Oncology, Hematology, and Infectious Diseases, Department of Medicine, Fukuoka University Hospital.
¹⁰ Department of Hematology, Sasebo City General Hospital.
¹¹ Department of Hematology, Oita Prefectural Hospital.
¹² Department of Hematology, Japanese Red Cross Nagasaki Genbaku Hospital.
¹³ Department of Hematology, Oita University Hospital.
¹⁴ Department of Dermatology, Imamura General Hospital.
¹⁵ Department of Hematology, Kumamoto University Hospital.
¹⁶ Department of Hematology, National Hospital Organization Kyushu Cancer Centre Hospital; Department of Cell Therapy National Hospital Organization Kyushu Cancer Centre Hospital.
¹⁷ Osaka Laboratory, Repertoire Genesis Incorporation.
¹⁸ Department of Immunology, Nagoya University Graduate School of Medicine; Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences. [email protected].

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Gene Rearrangement, B-Lymphocyte, Heavy Chain
Humans
Immunoglobulin Class Switching / genetics
Immunoglobulin Heavy Chains / genetics
Immunoglobulin gamma-Chains / genetics
Leukemia-Lymphoma, Adult T-Cell* / genetics

Substances

Immunoglobulin Heavy Chains
Immunoglobulin gamma-Chains

Grants and funding

Funding: This work was supported by a Grant-in-Aid for Early-Career Scientists (N 21K15567 to HH), a Grant-in-Aid for Challenging Research (Exploratory) (N 21K19900 to TI), a Grant-in-Aid for Scientific Research (B) (N 22H02918 to TI), and by Grants-in-Aid from the Japan Agency for Medical Research and Development (N 21ae0101074h0001, and 22ae0101074h0001 to RU).