Radiation-Induced Laryngeal Mucous Membrane Pemphigoid

Ann Otol Rhinol Laryngol. 2023 Oct;132(10):1261-1264. doi: 10.1177/00034894221139121. Epub 2022 Nov 26.

Abstract

Objectives: Bullous pemphigoid has previously been linked to radiotherapy, but here we report the first case of MMP suspected to be a consequence of RT.

Methods: The patient described is an 85-year-old male who underwent RT to treat squamous cell carcinoma of the palatine tonsil. Shortly after therapy, the patient developed blisters with worsening dyspnea and dysphonia.

Results: This patient was successfully treated with a combination of oral immunosuppressants and surgical intervention.

Conclusion: This incident underscores that not all episodes of mucosal ulceration following radiation are a result of mucositis and MMP should be considered in the differential.

Level of evidence: Level 4.

Keywords: bullous pemphigoid; mucous membrane pemphigoid; radiation therapy; supraglottic stenosis.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Carcinoma, Squamous Cell* / radiotherapy
  • Humans
  • Immunosuppressive Agents
  • Male
  • Mucous Membrane / pathology
  • Pemphigoid, Benign Mucous Membrane* / chemically induced
  • Pemphigoid, Benign Mucous Membrane* / diagnosis
  • Pemphigoid, Benign Mucous Membrane* / radiotherapy
  • Pemphigoid, Bullous* / pathology

Substances

  • Immunosuppressive Agents