Specialized cells for building tissue bridges

April M Craft; Jenna Galloway

doi:10.1016/j.stem.2022.11.009

Specialized cells for building tissue bridges

Cell Stem Cell. 2022 Dec 1;29(12):1615-1616. doi: 10.1016/j.stem.2022.11.009.

Authors

April M Craft¹, Jenna Galloway²

Affiliations

¹ Department of Orthopedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Stem Cells & Regenerative Biology, Harvard University, Cambridge, MA, USA; Harvard Stem Cell Institute, Cambridge, MA, USA. Electronic address: [email protected].
² Harvard Stem Cell Institute, Cambridge, MA, USA; Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.

PMID: 36459962
DOI: 10.1016/j.stem.2022.11.009

Abstract

Fang and colleagues provide a comprehensive transcriptomic analysis of the cell types occupying the interface between tendon and bone, the enthesis. They establish a framework for understanding enthesis maturation and identify a potent Gli1-lineage progenitor with clonogenicity and multipotency that improves enthesis healing in an adult injury model.

Publication types

Comment

MeSH terms

Adult
Gene Expression Profiling*
Humans
Wound Healing*

Grants and funding

R01 AR055580/AR/NIAMS NIH HHS/United States