Incidence of healthcare-associated Clostridioides difficile infection in a quaternary referral university hospital in Brazil

Daniela S Braga; Daniela F Oliveira; Natane V Lourenço; Gabriela M Carvalho; Vitória M L R Rezende; Tainá V Lourenço; Rodrigo O S Silva; Ed J Kuijper; Eduardo G Vilela

doi:10.1016/j.anaerobe.2022.102672

Incidence of healthcare-associated Clostridioides difficile infection in a quaternary referral university hospital in Brazil

Anaerobe. 2023 Feb:79:102672. doi: 10.1016/j.anaerobe.2022.102672. Epub 2022 Nov 26.

Authors

Daniela S Braga¹, Daniela F Oliveira¹, Natane V Lourenço¹, Gabriela M Carvalho², Vitória M L R Rezende¹, Tainá V Lourenço¹, Rodrigo O S Silva³, Ed J Kuijper⁴, Eduardo G Vilela¹

Affiliations

¹ Faculdade de Medicina, Universidade Federal de Minas Gerais, Brazil; Instituto Alfa de Gastroenterologia, Hospital das Clínicas da Universidade Federal de Minas Gerais, Brazil.
² Veterinary School, Universidade Federal de Minas Gerais, Antônio Carlos Avenue, 6627. Belo Horizonte, MG, 31.270-901, Brazil.
³ Veterinary School, Universidade Federal de Minas Gerais, Antônio Carlos Avenue, 6627. Belo Horizonte, MG, 31.270-901, Brazil. Electronic address: [email protected].
⁴ Expertise Center for Clostridioides difficile infections, at Department of Medical Microbiology, Leiden University Medical Center, Leiden, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.

PMID: 36471553
DOI: 10.1016/j.anaerobe.2022.102672

Abstract

Clostridioides difficile infection (CDI) is an important cause of diarrhea in hospitals worldwide. The incidence of CDI in Latin America has not yet been standardized. To fill this gap, the present study performed a daily active surveillance, for three months, between April to July of 2021, at a quaternary referral university hospital in Brazil. The incidence density was 9.2 cases per 10,000 patient-days. Cases were associated mostly with ribotypes 014 and 106 (44% and 22%, respectively). Ribotype 027 was not identified. The findings strongly reinforce the need for broad epidemiological studies on the incidence of CDI in Brazilian hospitals to increase the understanding, prevention, and treatment of this infection.

Keywords: Clostridioides; Diarrhea; Healthcare-associated; Incidence.

MeSH terms

Brazil / epidemiology
Clostridioides difficile* / genetics
Clostridium Infections* / epidemiology
Cross Infection* / epidemiology
Delivery of Health Care
Hospitals, University
Humans
Incidence
Referral and Consultation
Ribotyping