Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infections occurring in healthcare workers after booster vaccination: A comparison of delta versus omicron variants

Kimberly D Reeves; Christopher M Polk; Laura A Cox; Robert T Fairman; Gregory A Hawkins; Catherine L Passaretti; Mindy M Sampson

doi:10.1017/ash.2022.239

Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infections occurring in healthcare workers after booster vaccination: A comparison of delta versus omicron variants

Antimicrob Steward Healthc Epidemiol. 2022 Aug 18;2(1):e143. doi: 10.1017/ash.2022.239. eCollection 2022.

Authors

Kimberly D Reeves^{1

2}, Christopher M Polk³, Laura A Cox^{1

2}, Robert T Fairman^{3

4}, Gregory A Hawkins^{1

5}, Catherine L Passaretti³, Mindy M Sampson³

Affiliations

¹ Center for Precision Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolia.
² Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.
³ Division of Infection Diseases, Department of Medicine, Atrium Health, Charlotte, North Carolina.
⁴ Department of Health Policy & Behavioral Sciences, School of Public Health, Georgia State University, Atlanta, Georgia.
⁵ Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Abstract

In this study, we used genomic sequencing to identify variants of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) in healthcare workers with coronavirus disease 2019 (COVID-19) after receiving a booster vaccination. We compared symptoms, comorbidities, exposure risks, and vaccine history between the variants. Postbooster COVID-19 cases increased as the SARS-CoV-2 omicron variant predominated.