Avoidance behavior and experience-dependent tolerance in response to bitter compounds in Caenorhabditis elegans

Seiryu Ishikawa; Chiharu Iida; Yuka Takezawa; Kyoko Chiba; Eriko Kage-Nakadai

doi:10.1093/bbb/zbac200

Avoidance behavior and experience-dependent tolerance in response to bitter compounds in Caenorhabditis elegans

Biosci Biotechnol Biochem. 2023 Feb 24;87(3):314-319. doi: 10.1093/bbb/zbac200.

Authors

Seiryu Ishikawa¹, Chiharu Iida¹, Yuka Takezawa¹, Kyoko Chiba², Eriko Kage-Nakadai^{1

2

3}

Affiliations

¹ Graduate School of Human Life Science, Osaka City University, Osaka, Japan.
² Department of Food and Nutrition, Faculty of Human Life Science, Osaka City University, Osaka, Japan.
³ Graduate School of Human Life and Ecology, Osaka Metropolitan University, Osaka, Japan.

PMID: 36494200
DOI: 10.1093/bbb/zbac200

Abstract

This study investigates the mechanisms governing experience-dependent tolerance of bitter compounds in Caenorhabditis elegans. The nematodes showed an aversion to nicotinamide, MgCl2, isoleucine, and arginine in a Gα-dependent manner. Worms furthermore displayed diminished avoidance of MgCl2 upon MgCl2-preconditioning at the larval stages. AIY interneurons have been suggested to be involved in experience-dependent behavioral plasticity.

Keywords: Caenorhabditis elegans; behavioral plasticity; bitterness.

MeSH terms

Animals
Avoidance Learning
Caenorhabditis elegans Proteins*
Caenorhabditis elegans* / physiology
Magnesium Chloride

Substances

Caenorhabditis elegans Proteins
Magnesium Chloride