Frequency of translocation of USP-6 in the aneurysmal bone cyst of the jaw

Background: This study aims to detect USP6 translocation in aneurysmal cysts located in the jaw and to give an overview of demographic data.

Methods: The present retrospective cohort study includes 10 patients who underwent surgery due to an aneurysmal cyst of the jaw in our hospital between 2002 and 2021. Unstained formalin-fixed and paraffin-embedded tissue sections cut at 4 μm thickness were subjected to USP6 FISH testing.

Results: All patients underwent surgical treatment. In four of ten patients (40%) USP-6-translocations have been found.

Conclusion: Based on the study, it is hypothesized that the aneurysmal bone cyst of the jaw bone may be subject to a different pathomechanism than that of the long bones. Therefore, it seems conceivable that the primary cause of aneurysmal bone cysts in the jaw might differ.