A case of vasovagal syncope associated with carotid sinus hypersensitivity: Effectiveness of tilt training and subsequent squatting

A 43-year-old man fainted on a train and was transported to our hospital by an ambulance. No structural heart diseases or neurological abnormalities were observed. Electrocardiogram on admission demonstrated a junctional escape rhythm with bradycardia at 39 bpm. Sick sinus syndrome was excluded from electrophysiological studies. He had lifelong episodes of recurrent syncope that occurred due to emotional stress in daily life and pain associated with medical procedures. Since both the head-up tilt and carotid sinus massage tests showed a positive response, he was diagnosed with vasovagal syncope (VVS) and carotid sinus hypersensitivity. He was encouraged to continue the modified tilt training at home, which included leaning on the wall and squatting if leaning was intolerant. Thereafter, syncope was not observed in his daily life. This case highlights the importance of an accurate diagnosis, full education, and home training for recurrent syncope. This case also suggests that the carotid sinus may be involved in the neural network that causes VVS.

Learning objective: Reflex syncope includes both vasovagal syncope (VVS) and carotid sinus syndrome (CSS); however, VVS is discriminated from CSS according to current guidelines. We encountered a case of VVS associated with carotid sinus hypersensitivity. Recurrent syncope disappeared with modified tilt training characterized by conventional tilting and subsequent squatting when tilting was intolerant. This case indicates that the carotid sinus may be involved in the neural network responsible for VVS.