Potential implications of polyphenolic compounds in neurodegenerative diseases

Crit Rev Food Sci Nutr. 2024;64(16):5491-5514. doi: 10.1080/10408398.2022.2155106. Epub 2022 Dec 16.

Abstract

Neurodegenerative diseases are common chronic diseases related to progressive damage to the nervous system. Current neurodegenerative diseases present difficulties and despite extensive research efforts to develop new disease-modifying therapies, there is still no effective treatment for halting the neurodegenerative process. Polyphenols are biologically active organic compounds abundantly found in various plants. It has been reported that plant-derived dietary polyphenols may improve some disease states and promote health. Emerging pieces of evidence indicate that polyphenols are associated with neurodegenerative diseases. This review aims to overview the potential neuroprotective roles of polyphenols in most common neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, epilepsy, and ischemic stroke.

Keywords: Alzheimer’s disease; Parkinson’s disease; Polyphenols; epilepsy; ischemic stroke.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease* / drug therapy
  • Animals
  • Epilepsy / drug therapy
  • Humans
  • Ischemic Stroke / drug therapy
  • Ischemic Stroke / prevention & control
  • Neurodegenerative Diseases* / drug therapy
  • Neuroprotective Agents* / pharmacology
  • Neuroprotective Agents* / therapeutic use
  • Parkinson Disease* / drug therapy
  • Polyphenols* / pharmacology

Substances

  • Polyphenols
  • Neuroprotective Agents