Hydropersulfides are endogenous antioxidants that inhibit ferroptosis

Mike Lange; James A Olzmann

doi:10.1016/j.chembiol.2022.11.011

Hydropersulfides are endogenous antioxidants that inhibit ferroptosis

Cell Chem Biol. 2022 Dec 15;29(12):1661-1663. doi: 10.1016/j.chembiol.2022.11.011.

Authors

Mike Lange¹, James A Olzmann²

Affiliations

¹ Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
² Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA. Electronic address: [email protected].

PMID: 36525952
DOI: 10.1016/j.chembiol.2022.11.011

Abstract

Hydropersulfides are implicated in cellular responses to oxidative stress. In two landmark papers, Barayeu et al. and Wu et al. reveal that endogenous hydropersulfides are hydrogen atom donors that scavenge lipid radicals, thereby preventing lipid peroxidation and ferroptosis. Thus, the pathways governing hydropersulfides may represent a new cellular ferroptosis suppression system.

MeSH terms

Antioxidants / metabolism
Antioxidants / pharmacology
Ferroptosis*
Lipid Peroxidation
Oxidative Stress

Substances

Antioxidants