Age Related Cognitive Function Was Positively Associated with Diastolic Pressure and Negatively Associated with Antibody Expression in Chinese Oldest-Old and Centenarian Adults

Purpose: Age related cognitive function (ARCF) is of increasing concern in an aging population. Few studies have examined the relationships between ARCF and antibody expression or blood pressure, particularly in older populations. Large sample sizes are needed to elucidate these relationships to inform better strategies for identification and prevention of cognitive decline. The present study was designed to investigate these relationships in Chinese oldest-old and centenarian adults.

Patients and methods: A household survey was performed that included 436 centenarians and 520 oldest-old adults (80-99 years) residing in 16 cities and counties of Hainan province, China. ARCF was assessed using the mini-mental state examination.

Results: The median age of participants in this study was 92 years, with a range of 80 to 116 years. Females accounted for 68.5% (655) of the participant pool. Multivariate linear regression analysis showed that age [Exp(B): -0.220, 95% confidence interval (CI): -0.270--0.169], female gender [Exp(B): -3.459, 95% CI:-4.458--2.460], Han ethnicity [Exp(B): -1.732, 95% CI: -2.693--0.772], serum creatinine [Exp(B): -0.019, 95% CI: -0.037--0.001], immunoglobulin light chain KAP [Exp(B): -0.008, 95% CI: -0.015-0.000], and anti-ribonucleoprotein antibody [Exp(B): -6.393, 95% CI: -10.898--1.887] were negatively associated with ARCF (P < 0.05). Coronary artery disease [Exp(B): 1.957, 95% CI: 0.170-3.744] and diastolic pressure [Exp(B): 0.041, 95% CI: 0.002-0.079] were positively associated with ARCF (P < 0.05).

Conclusion: ARCF was positively associated with diastolic pressure and negatively associated with antibody expression in Chinese oldest-old and centenarian adults.