IgE-expressing long-lived plasma cells in persistent sensitization

Persistent allergies affect the quality of life of patients and increase economic burdens. Many clinical observations indicate the presence of IgE⁺ long-lived plasma cells (LLPCs), which account for the persistent secretion of specific IgE; however, the characteristics of the IgE⁺ LLPCs have yet to be identified clearly. In this review, we summarized the generation of IgE⁺ PCs, discussed the prosurvival factors in the microenvironment, and reviewed the unique IgE-BCR signaling, which may bring insights into understanding the survival mechanisms of IgE⁺ LLPCs.