Photoresponsive polymeric microneedles: An innovative way to monitor and treat diseases

Parbeen Singh; Brian Youden; Andrew Carrier; Ken Oakes; Mark Servos; Runqing Jiang; Sujing Lin; Thanh D Nguyen; Xu Zhang

doi:10.1016/j.jconrel.2022.12.036

Photoresponsive polymeric microneedles: An innovative way to monitor and treat diseases

J Control Release. 2023 Jan:353:1050-1067. doi: 10.1016/j.jconrel.2022.12.036. Epub 2022 Dec 22.

Authors

Parbeen Singh¹, Brian Youden², Andrew Carrier³, Ken Oakes⁴, Mark Servos⁵, Runqing Jiang⁶, Sujing Lin⁷, Thanh D Nguyen⁸, Xu Zhang⁹

Affiliations

¹ Department of Mechanical Engineering, University of Connecticut, United States; School of Food and Drug, Shenzhen Key Laboratory of Fermentation Purification and Analysis, Shenzhen Polytechnic, Shenzhen 518055, China.
² Department of Chemistry, Cape Breton University, 1250 Grand Lake Road, Sydney, Nova Scotia B1P 6L2, Canada; Department of Biology, University of Waterloo, 200 University Ave W, Waterloo, Ontario N2L 3G1, Canada.
³ Department of Chemistry, Cape Breton University, 1250 Grand Lake Road, Sydney, Nova Scotia B1P 6L2, Canada.
⁴ Department of Biology, Cape Breton University, 1250 Grand Lake Road, Sydney, Nova Scotia B1P 6L2, Canada.
⁵ Department of Biology, University of Waterloo, 200 University Ave W, Waterloo, Ontario N2L 3G1, Canada.
⁶ Department of Medical Physics, Grand River Regional Cancer Centre, Kitchener, Ontario N2G 1G3, Canada.
⁷ School of Food and Drug, Shenzhen Key Laboratory of Fermentation Purification and Analysis, Shenzhen Polytechnic, Shenzhen 518055, China. Electronic address: [email protected].
⁸ Department of Mechanical Engineering, University of Connecticut, United States. Electronic address: [email protected].
⁹ Department of Chemistry, Cape Breton University, 1250 Grand Lake Road, Sydney, Nova Scotia B1P 6L2, Canada. Electronic address: [email protected].

PMID: 36549390
DOI: 10.1016/j.jconrel.2022.12.036

Abstract

Microneedles (MN) technology is an emerging technology for the transdermal delivery of therapeutics. When combined with photoresponsive (PR) materials, MNs can deliver therapeutics precisely and effectively with enhanced efficacy or synergistic effects. This review systematically summarizes the therapeutic applications of PRMNs in cancer therapy, wound healing, diabetes treatment, and diagnostics. Different PR approaches to activate and control the release of therapeutic agents from MNs are also discussed. Overall, PRMNs are a powerful tool for stimuli-responsive controlled-release therapeutic delivery to treat various diseases.

Keywords: Cancer therapy; Diabetes treatment; Diagnostics; Microneedles; Phototherapies; Wound healing.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Administration, Cutaneous
Drug Delivery Systems*
Needles
Polymers
Skin*

Substances

Polymers