Ictal fMRI: Mapping Seizure Topography with Rhythmic BOLD Oscillations

David Fischer; Otto Rapalino; Matteo Fecchio; Brian L Edlow

doi:10.3390/brainsci12121710

Ictal fMRI: Mapping Seizure Topography with Rhythmic BOLD Oscillations

Brain Sci. 2022 Dec 13;12(12):1710. doi: 10.3390/brainsci12121710.

Authors

David Fischer¹, Otto Rapalino², Matteo Fecchio³, Brian L Edlow^{3

4}

Affiliations

¹ Division of Neurocritical Care, Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA.
² Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA.
³ Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
⁴ Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

Abstract

Functional magnetic resonance imaging (fMRI) has shown elevations in the blood-oxygen-level-dependent (BOLD) signal associated with, but insensitive for, seizure. Rather than evaluating absolute BOLD signal elevations, assessing rhythmic oscillations in the BOLD signal with fMRI may improve the accuracy of seizure mapping. We report a case of a patient with non-convulsive, right hemispheric seizures who underwent fMRI. Unbiased processing methods revealed a map of rhythmically oscillating BOLD signal over the cortical region affected by seizure, and synchronous BOLD signal in the contralateral cerebellum. High-resolution fMRI may help identify the spatial topography of seizure and provide insights into seizure physiology.

Keywords: fMRI; seizure; status epilepticus.

Publication types

Case Reports

Abstract

Publication types

Grants and funding