Diagnostic and therapeutic algorithms for monogenic autoinflammatory diseases presenting with recurrent fevers among adults

Rheumatology (Oxford). 2023 Aug 1;62(8):2665-2672. doi: 10.1093/rheumatology/keac712.

Abstract

Autoinflammatory diseases (AIDs) are defined as disorders of innate immunity. They were initially defined in contrast to autoimmune diseases because of the lack of involvement of the adaptive immune system and circulating autoantibodies. The four monogenic AIDs first described are called the 'historical' AIDs and include FMF (associated with MEFV mutations), cryopyrinopathies (associated with NLRP3 mutations), TNF receptor-associated periodic syndrome (associated with TNFRSF1A mutations) and mevalonate kinase deficiency (MKD; associated with MVK mutations). In the last 10 years, >50 new monogenic AIDs have been discovered due to genetic advances. The most important discovery for adult patients is VEXAS syndrome associated with somatic UBA1 mutations leading to an AID affecting mostly elderly men. Diagnosis of monogenic AIDs is based on personal and family history and detailed analysis of symptoms associated with febrile attacks in the context of elevated peripheral inflammatory markers. This review proposes a practical approach for the diagnosis of the main monogenic AIDs among adult patients.

Keywords: VEXAS syndrome; autoinflammation; familial Mediterranean fever; monogenic autoinflammatory disease; recurrent fever.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • Cryopyrin-Associated Periodic Syndromes* / diagnosis
  • Cryopyrin-Associated Periodic Syndromes* / drug therapy
  • Cryopyrin-Associated Periodic Syndromes* / genetics
  • Familial Mediterranean Fever* / diagnosis
  • Familial Mediterranean Fever* / drug therapy
  • Familial Mediterranean Fever* / genetics
  • Fever / etiology
  • Fever / genetics
  • Hereditary Autoinflammatory Diseases* / diagnosis
  • Hereditary Autoinflammatory Diseases* / genetics
  • Humans
  • Male
  • Mevalonate Kinase Deficiency* / diagnosis
  • Mevalonate Kinase Deficiency* / genetics
  • Myelodysplastic Syndromes
  • Pyrin
  • Skin Diseases, Genetic

Substances

  • MEFV protein, human
  • Pyrin

Supplementary concepts

  • VEXAS syndrome