Mutagenicity of actinomycin D in mammalian cells due to clastogenic effects

D M DeMarini; K H Brock; C L Doerr; M M Moore

doi:10.1016/0165-7992(87)90113-8

Mutagenicity of actinomycin D in mammalian cells due to clastogenic effects

Mutat Res. 1987 Oct;192(2):151-5. doi: 10.1016/0165-7992(87)90113-8.

Authors

D M DeMarini¹, K H Brock, C L Doerr, M M Moore

Affiliation

¹ Genetic Toxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711.

PMID: 3657844
DOI: 10.1016/0165-7992(87)90113-8

Abstract

Actinomycin D was clastogenic and mutagenic in L5178Y/TK +/- -3.7.2C mouse lymphoma cells. The majority of the mutants were small colonies, indicating that actinomycin D acts primarily by a clastogenic mechanism.

MeSH terms

Animals
Chromosome Aberrations*
Dactinomycin / pharmacology*
Leukemia L1210
Mice
Mutagenicity Tests
Mutagens / pharmacology*
Mutation
Neoplasm Proteins / genetics
Thymidine Kinase / genetics
Tumor Cells, Cultured / drug effects*
Tumor Stem Cell Assay

Substances

Mutagens
Neoplasm Proteins
Dactinomycin
Thymidine Kinase