Regulatory mechanism of icariin in cardiovascular and neurological diseases

Yuling Wang; Chang Shang; Yang Zhang; Laiyun Xin; Linke Jiao; Mi Xiang; Zihuan Shen; Chen Chen; Fan Ding; Yingdong Lu; Xiangning Cui

doi:10.1016/j.biopha.2022.114156

Regulatory mechanism of icariin in cardiovascular and neurological diseases

Biomed Pharmacother. 2023 Feb:158:114156. doi: 10.1016/j.biopha.2022.114156. Epub 2022 Dec 28.

Authors

Yuling Wang¹, Chang Shang², Yang Zhang³, Laiyun Xin⁴, Linke Jiao⁵, Mi Xiang⁶, Zihuan Shen⁷, Chen Chen⁸, Fan Ding⁹, Yingdong Lu¹⁰, Xiangning Cui¹¹

Affiliations

¹ Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Beijing University of Chinese Medicine, Beijing, China. Electronic address: [email protected].
² Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Beijing University of Chinese Medicine, Beijing, China. Electronic address: [email protected].
³ Shandong University of Chinese Medicine, Shandong, China. Electronic address: [email protected].
⁴ Shandong University of Chinese Medicine, Shandong, China. Electronic address: [email protected].
⁵ Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Beijing University of Chinese Medicine, Beijing, China. Electronic address: [email protected].
⁶ Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Beijing University of Chinese Medicine, Beijing, China. Electronic address: [email protected].
⁷ Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Beijing University of Chinese Medicine, Beijing, China. Electronic address: [email protected].
⁸ Beijing University of Chinese Medicine, Beijing, China. Electronic address: [email protected].
⁹ Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Beijing University of Chinese Medicine, Beijing, China. Electronic address: [email protected].
¹⁰ Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China. Electronic address: [email protected].
¹¹ Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China. Electronic address: [email protected].

PMID: 36584431
DOI: 10.1016/j.biopha.2022.114156

Abstract

Cardiovascular diseases (CVDs) and neurological diseases are widespread diseases with substantial rates of morbidity and mortality around the world. For the past few years, the preventive effects of Chinese herbal medicine on CVDs and neurological diseases have attracted a great deal of attention. Icariin (ICA), the main constituent of Epimedii Herba, is a flavonoid. It has been shown to provide neuroprotection, anti-tumor, anti-osteoporosis, and cardiovascular protection. The endothelial protection, anti-inflammatory, hypolipidemic, antioxidative stress, and anti-apoptosis properties of ICA can help stop the progression of CVDs and neurological diseases. Therefore, our review summarized the known mechanisms and related studies of ICA in the prevention and treatment of cardio-cerebrovascular diseases (CCVDs), to better understand its therapeutic potential.

Keywords: Cardiovascular disease; Icariin; Mechanism; Neurological disease; Traditional Chinese Medicine.

Publication types

Review

MeSH terms

Anti-Inflammatory Agents / therapeutic use
Drugs, Chinese Herbal* / pharmacology
Drugs, Chinese Herbal* / therapeutic use
Flavonoids / pharmacology
Flavonoids / therapeutic use
Humans
Osteoporosis* / drug therapy
Oxidative Stress

Substances

icariin
Drugs, Chinese Herbal
Flavonoids
Anti-Inflammatory Agents